TABLE 2 | Concomitance of chronic inflammatory and autoimmune diseases

From the following article:

Detecting shared pathogenesis from the shared genetics of immune-related diseases

Alexandra Zhernakova, Cleo C. van Diemen & Cisca Wijmenga

Nature Reviews Genetics 10, 43-55 (January 2009)

doi:10.1038/nrg2489

DiseaseOther diseases seen in patientsFamiliar clusteringRefs
Ankylosing spondylitisUlcerative colitis (5%), Crohn's disease (3%), psoriasis (16%)IBD* (7%), psoriasis (10%)94
AsthmaCrohn's disease, ulcerative colitisND95
AIT disease (including Graves' and Hashimoto's disease)Rheumatoid arthritis (1.4–17.6%), T1D (3–15%), coeliac disease (5.4%)ND4,96
Coeliac diseaseAsthma (24.6%), SLE (2.4%), AIT (5%), T1D (5%), psoriasisND97, 98, 99
Crohn's diseaseRheumatoid arthritis (1.7–1.6%), asthma (7.1–13.0%), psoriasis (1.7–1.9%), coeliac disease (19%), multiple sclerosis (0.4%)Psoriasis (10%)95, 100, 101, 102
Multiple sclerosisAIT (0.5–3.9%), psoriasis (6%), IBD (3%)*, rheumatoid arthritis (0.35–2.4%), T1D (0–2.6%)AIT (10%), psoriasis (6%), IBD (3%)*, rheumatoid arthritis (2%)4
PsoriasisCrohn's disease, ulcerative colitis, coeliac diseaseND95
Rheumatoid arthritisAsthma (10.0%), T1D (0.3–6%), AIT (0.5–9.8%)AIT (2.1%), T1D (0.44), SLE (0.36%), multiple sclerosis (0.29%)4,85,99
SLEDiabetes mellitus (11.6%)ND103
T1DCoeliac disease (4–9%), AIT (0–24%), asthma (5%), rheumatoid arthritis (2%)Coeliac disease (6%), AIT (8%) (2.7%), rheumatoid arthritis (0.97%)4,99,104,105
Ulcerative colitisRheumatoid arthritis (1.1–1.6%), asthma (7.9–12.0%), psoriasis (1.7–1.8%), multiple sclerosis (0.4–0.54%)ND95,102
*No discrimination made between Crohn's disease and ulcerative colitis. AIT, autoimmune thyroid disease; IBD, inflammatory bowel disease; ND, not determined; SLE, systemic lupus erythematosus; T1D, type 1 diabetes.

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