Figures and Tables

From the following article:

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Michael Haberland, Rusty L. Montgomery & Eric N. Olson

Nature Reviews Genetics 10, 32-42 (January 2009)

doi:10.1038/nrg2485

Figure 1 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Figure 1

The histone deacetylase (HDAC) superfamily, showing protein domains, loss-of-function phenotypes in mice and time point of lethality of the knockouts.

Figure 2 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Figure 2

Control of heart development by histone deacetylase 1 (HDAC1) and HDAC2.

Figure 3 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Figure 3

Control of chondrocyte hypertrophy by histone deacetylase 4 (HDAC4).

Figure 4 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Figure 4

Control of pathological cardiac hypertrophy by class IIa histone deacetylases (HDACs).

Figure 5 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Figure 5

Control of slow myofibre gene expression by class IIa histone deacetylases (HDACs).

Figure 6 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Figure 6

Control of endothelial integrity by histone deacetylase 7 (HDAC7).

Table 1 - The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Table 1

Clinical and experimental use of histone deacetlyase (HDAC) inhibitors in diverse disease states