Review
Nature Reviews Genetics 10, 9-18 (January 2009) | doi:10.1038/nrg2483
Genotype–phenotype databases: challenges and solutions for the post-genomic era
Gudmundur A. Thorisson1, Juha Muilu2 & Anthony J. Brookes1 About the authors
Abstract
The flow of research data concerning the genetic basis of health and disease is rapidly increasing in speed and complexity. In response, many projects are seeking to ensure that there are appropriate informatics tools, systems and databases available to manage and exploit this flood of information. Previous solutions, such as central databases, journal-based publication and manually intensive data curation, are now being enhanced with new systems for federated databases, database publication, and more automated management of data flows and quality control. Along with emerging technologies that enhance connectivity and data retrieval, these advances should help to create a powerful knowledge environment for genotype–phenotype information.
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Author affiliations
- Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK.
- Institute for Molecular Medicine Finland, University of Helsinki, Haartmaninkatu 8, FIN-00290, Helsinki, Finland.
Correspondence to: Anthony J. Brookes1 Email: ajb97@leicester.ac.uk
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