NPG Library
Below is a selection of recent Research Highlights, Reviews, Research Articles, Perspectives and Commentaries that have been published by Nature Publishing Group journals on the topic of Statistical Analysis.
Research Highlights
Mapping the common variation
Magdalena Skipper
doi:10.1038/nrg1752
Nature Reviews Genetics 6, 874 (2005)
Closing in on the hotspots
Magdalena Skipper
doi:10.1038/nrg1586
Nature Reviews Genetics 6, 254-255 (2005)
Reviews
Family-based designs in the age of large-scale gene-association studies
Nan M. Laird and Christoph Lange
doi:10.1038/nrg1839
Nature Reviews Genetics 7, 385-394 (2006)
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines
Michael W. Smith and Stephen J. O'Brien
doi:10.1038/nrg1657
Nature Reviews Genetics 6, 623-632 (2005)
Complex trait mapping in isolated populations: are specific statistical methods required?
Catherine Bourgain and Emmanuelle Génin
doi:10.1038/sj.ejhg.5201400
European Journal of Human Genetics 13, 698-706 (2005)
Genome-wide association studies for common diseases and complex traits
Joel N. Hirschhorn and Mark J. Daly
doi:10.1038/nrg1521
Nature Reviews Genetics 6, 95-108 (2005)
Genome-wide association studies: theoretical and practical concerns
William Y. S. Wang, Bryan J. Barratt, David G. Clayton and John A. Todd
doi:10.1038/nrg1522
Nature Reviews Genetics 6, 109-118 (2005)
Association studies for finding cancer-susceptibility genetic variants
Paul D. P. Pharoah, Alison M. Dunning, Bruce A. J. Ponder and Douglas F. Easton
doi:10.1038/nrc1476
Nature Reviews Cancer 4, 850-860 (2004)
The use of pedigree, sib-pair and association studies of common diseases for genetic mapping and epidemiology
Nelson Freimer and Chiara Sabatti
doi:10.1038/ng1433
Nature Genetics 36, 1045-1051 (2004)
Encoded evidence: DNA in forensic analysis
Mark A. Jobling and Peter Gill
doi:10.1038/nrg1455
Nature Reviews Genetics 5, 739-751 (2004)
What is Bayesian statistics?
Sean R Eddy
doi:10.1038/nbt0904-1177
Nature Biotechnology 22, 1177-1178 (2004)
The Bayesian revolution in genetics
Mark A. Beaumont and Bruce Rannala
doi:10.1038/nrg1318
Nature Reviews Genetics 5, 251-261 (2004)
The complex interplay among factors that influence allelic association
Krina T. Zondervan and Lon R. Cardon
doi:10.1038/nrg1270
Nature Reviews Genetics 5, 89-100 (2004)
In silico method for inferring genotypes in pedigrees
Joshua T Burdick, Wei-Min Chen, Gonçalo R Abecasis and Vivian G Cheung
doi:10.1038/ng1863
Nature Genetics 38, 1002-1004 (2006)
Principal components analysis corrects for stratification in genome-wide association studies
Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick and David Reich
doi:10.1038/ng1847
Nature Genetics 38, 904-909 (2006)
The value of gene-based selection of tag SNPs in genome-wide association studies
Steven Wiltshire, Paul I W de Bakker, Mark J Daly
doi:10.1038/sj.ejhg.5201678
European Journal of Human Genetics advance online publication 28 June 2006
Evaluating coverage of genome-wide association studies
Jeffrey C Barrett and Lon R Cardon
doi:10.1038/ng1801
Nature Genetics 38, 659-662 (2006)
Evaluating and improving power in whole-genome association studies using fixed marker sets
Itsik Pe'er, Paul I W de Bakker, Julian Maller, Roman Yelensky, David Altshuler and Mark J Daly
doi:10.1038/ng1816
Nature Genetics 38, 663-667 (2006)
An utter refutation of the 'Fundamental Theorem of the HapMap'
Joseph D Terwilliger and Tero Hiekkalinna
doi:10.1038/sj.ejhg.5201583
European Journal of Human Genetics 14, 426�437 (2006)
Validity of tagging SNPs across populations for association studies
Albert Tenesa and Malcolm G Dunlop
doi:10.1038/sj.ejhg.5201554
European Journal of Human Genetics 14, 357-363 (2006)
A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
Jianming Yu, Gael Pressoir, William H Briggs, Irie Vroh Bi, Masanori Yamasaki, John F Doebley, Michael D McMullen, Brandon S Gaut, Dahlia M Nielsen, James B Holland, Stephen Kresovich, Edward S Buckler
doi:10.1038/ng1702
Nature Genetics 38, 203-208 (2006)
Clustering of haplotypes based on phylogeny: how good a strategy for association testing?
Claire Bardel, Pierre Darlu and Emmanuelle Génin
doi:10.1038/sj.ejhg.5201501
European Journal of Human Genetics 14, 202-206 (2006)
Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
Andrew D Skol, Laura J Scott, Gonçalo R Abecasis and Michael Boehnke
doi:10.1038/ng1706
Nature Genetics 38, 209-213 (2006)
An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets
Eleftheria Zeggini, William Rayner, Andrew P Morris, Andrew T Hattersley, Mark Walker, Graham A Hitman, Panos Deloukas, Lon R Cardon and Mark I McCarthy
doi:10.1038/ng1670
Nature Genetics 37, 1320-1322 (2005)
Efficiency and power in genetic association studies
Paul I W de Bakker, Roman Yelensky, Itsik Pe'er, Stacey B Gabriel, Mark J Daly and David Altshuler
doi:10.1038/ng1669
Nature Genetics 37, 1217-1223 (2005)
Population structure, differential bias and genomic control in a large-scale, case-control association study
David G Clayton, Neil M Walker, Deborah J Smyth, Rebecca Pask, Jason D Cooper, Lisa M Maier, Luc J Smink, Alex C Lam, Nigel R Ovington, Helen E Stevens, Sarah Nutland, Joanna M M Howson, Malek Faham, Martin Moorhead, Hywel B Jones, Matthew Falkowski, Paul Hardenbol, Thomas D Willis and John A Todd
doi:10.1038/ng1653
Nature Genetics 37, 1243-1246 (2005)
Mapping determinants of human gene expression by regional and genome-wide association
Vivian G. Cheung, Richard S. Spielman, Kathryn G. Ewens, Teresa M. Weber, Michael Morley and Joshua T. Burdick
doi:10.1038/nature04244
Nature 437, 1365-1369 (2005)
Typing without calling the allele: a strategy for inferring SNP haplotypes
Tamar Barzuza, Jacques S Beckmann, Ron Shamir and Itsik Pe'er
doi:10.1038/sj.ejhg.5201440
European Journal of Human Genetics 13, 898-901 (2005)
Hardy–Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power
Georgia Salanti, Georgia Amountza, Evangelia E Ntzani and John P A Ioannidis
doi:10.1038/sj.ejhg.5201410
European Journal of Human Genetics 13, 840-848 (2005)
A Monte Carlo algorithm for computing the IBD matrices using incomplete marker information
Y Mao and S Xu
doi:10.1038/sj.hdy.6800564
Heredity 94, 305-315 (2005)
Epistasis: too often neglected in complex trait studies?
Örjan Carlborg and Chris S. Haley
doi:10.1038/nrg1407
Nature Reviews Genetics 5, 618-625 (2004)
An utter refutation of the 'Fundamental Theorem of the HapMap' by Terwilliger and Hiekkalinna
Duncan C Thomas and Daniel O Stram
doi:10.1038/sj.ejhg.5201697
European Journal of Human Genetics advance online publication, 2 August 2006
Association studies: a genome-wide association approach to mapping the genetic determinants of the transcriptome in human populations
Eric E Schadt
doi:10.1038/sj.ejhg.5201657
European Journal of Human Genetics 14, 891-893 (2006)
Statistical false positive or true disease pathway?
John A Todd
doi:10.1038/ng0706-731
Nature Genetics 38, 731-733 (2006)
Agnosticism and equity in genome-wide association studies
Christopher S Carlson
doi:10.1038/ng0606-605
Nature Genetics 38, 605-606 (2006)
Quantitative genetics: Wholesale analysis of genes, traits and microarrays
R B O'Hara
doi:10.1038/sj.hdy.6800857
Heredity advance online publication, 21 June 2006
A road map for efficient and reliable human genome epidemiology
John P A Ioannidis, Marta Gwinn, Julian Little, Julian P T Higgins, Jonine L Bernstein, Paolo Boffetta, Melissa Bondy, Molly S Bray, Paul E Brenchley, Patricia A Buffler, Juan Pablo Casas, Anand Chokkalingam, John Danesh, George Davey Smith, Siobhan Dolan, Ross Duncan, Nelleke A Gruis, Patricia Hartge, Mia Hashibe, David J Hunter, Marjo-Riitta Jarvelin, Beatrice Malmer, Demetrius M Maraganore, Julia A Newton-Bishop, Thomas R O'Brien, Gloria Petersen, Elio Riboli, Georgia Salanti, Daniela Seminara, Liam Smeeth, Emanuela Taioli, Nic Timpson, Andre G Uitterlinden, Paolo Vineis, Nick Wareham, Deborah M Winn, Ron Zimmern, Muin J Khoury and The Human Genome Epidemiology Network and the Network of Investigator Networks
doi:10.1038/ng0106-3
Nature Genetics 38, 3-5 (2006)
Power tools for human genetics
Leonid Kruglyak
doi:10.1038/ng1205-1299
Nature Genetics 37, 1299-1300 (2005)
Framework for a fully powered risk engine
doi:10.1038/ng1105-1153
Nature Genetics 37, 1153 (2005)
Partners in crime
Mark J Daly and David Altshuler
doi:10.1038/ng0405-337
Nature Genetics 37, 337-338 (2005)
Statistical Genetics: Usual suspects in complex disease
C P Ponting and L Goodstadt
doi:10.1038/sj.ejhg.5201354
European Journal of Human Genetics 13, 269-270 (2005)
Genomic Control to the extreme
B Devlin, Silviu-Alin Bacanu and Kathryn Roeder
doi:10.1038/ng1104-1129
Nature Genetics 36, 1129-1130 (2004)
Reply to "Genomic Control to the extreme"
Jonathan Marchini, Lon R Cardon, Michael S Phillips and Peter Donnelly
doi:10.1038/ng1104-1131
Nature Reviews Genetics 36, 1131 (2004)
