Nature Reviews Genetics Nature Reviews Genetics is an invaluable source of information in genetics and genomics. The journal’s scope covers the whole breadth of these and related fields, bringing readers cutting-edge Reviews on topics that range from molecular genetics to evolution to systems biology. By publishing Reviews, Progress, Comment, Analysis and Perspective articles, among which are Viewpoints from opinion-leaders, Nature Reviews Genetics provides a balanced and unique perspective of this exciting field which goes well beyond the conventional review, and appeals to students and established scientists alike. All articles are written by carefully chosen leaders in their field and subject to rigorous peer-review, resulting in each issue providing balanced, high-quality and authoritative articles. While experts appreciate the insights and thought-provoking syntheses provided by the high-calibre authors, non-specialists are helped by the glossary definitions, additional background information in the boxes and highlighted references. http://feeds.nature.com/nrg/rss/current Nature Publishing Group en © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Reviews Genetics © 2024 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com Nature Reviews Genetics https://www.nature.com/uploads/product/nrg/rss.gif http://feeds.nature.com/nrg/rss/current <![CDATA[Dynamics of ER stress-induced gene regulation in plants]]> https://www.nature.com/articles/s41576-024-00710-4 Nature Reviews Genetics, Published online: 18 March 2024; doi:10.1038/s41576-024-00710-4

Plants have uniquely adapted to manage endoplasmic reticulum stress triggered by protein misfolding. The authors review the dynamics of gene expression regulation underlying the unfolded protein response in plants, highlighting recent insights provided by systems-level approaches and omics data.]]>
Dae Kwan KoFederica Brandizzi doi:10.1038/s41576-024-00710-4 Nature Reviews Genetics, Published online: 2024-03-18; | doi:10.1038/s41576-024-00710-4 2024-03-18 Nature Reviews Genetics 10.1038/s41576-024-00710-4 https://www.nature.com/articles/s41576-024-00710-4
<![CDATA[Competition between sites of meiotic recombination in snakes]]> https://www.nature.com/articles/s41576-024-00722-0 Nature Reviews Genetics, Published online: 12 March 2024; doi:10.1038/s41576-024-00722-0

A study in Science reports that corn snakes use both PRDM9 and promoter-like features to direct meiotic recombination, indicating that these are not mutually exclusive.]]>
Kirsty Minton doi:10.1038/s41576-024-00722-0 Nature Reviews Genetics, Published online: 2024-03-12; | doi:10.1038/s41576-024-00722-0 2024-03-12 Nature Reviews Genetics 10.1038/s41576-024-00722-0 https://www.nature.com/articles/s41576-024-00722-0
<![CDATA[Short tandem repeats — how microsatellites became the currency of forensic genetics]]> https://www.nature.com/articles/s41576-024-00721-1 Nature Reviews Genetics, Published online: 11 March 2024; doi:10.1038/s41576-024-00721-1

Bruce Budowle and Antti Sajantila reflect on how short tandem repeats (STRs) became the primary markers of forensic genetics, including for developing investigative leads in criminal cases and humanitarian efforts.]]>
Bruce BudowleAntti Sajantila doi:10.1038/s41576-024-00721-1 Nature Reviews Genetics, Published online: 2024-03-11; | doi:10.1038/s41576-024-00721-1 2024-03-11 Nature Reviews Genetics 10.1038/s41576-024-00721-1 https://www.nature.com/articles/s41576-024-00721-1
<![CDATA[The regulatory landscape of chromatin accessibility]]> https://www.nature.com/articles/s41576-024-00719-9 Nature Reviews Genetics, Published online: 11 March 2024; doi:10.1038/s41576-024-00719-9

A study in Nature Genetics identifies many regulators of genome-wide chromatin accessibility and then reports the mechanistic underpinnings for one of the identified transcription factors.]]>
Henry Ertl doi:10.1038/s41576-024-00719-9 Nature Reviews Genetics, Published online: 2024-03-11; | doi:10.1038/s41576-024-00719-9 2024-03-11 Nature Reviews Genetics 10.1038/s41576-024-00719-9 https://www.nature.com/articles/s41576-024-00719-9
<![CDATA[Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications]]> https://www.nature.com/articles/s41576-024-00696-z Nature Reviews Genetics, Published online: 11 March 2024; doi:10.1038/s41576-024-00696-z

This Review highlights the diversity in sequence composition of disease-related short tandem repeats. The authors discuss how to detect non-canonical motifs in repeat sequences from sequencing data and review the molecular and clinical consequences of sequence composition changes.]]>
Indhu-Shree Rajan-BabuEgor DolzhenkoMichael A. EberleJan M. Friedman doi:10.1038/s41576-024-00696-z Nature Reviews Genetics, Published online: 2024-03-11; | doi:10.1038/s41576-024-00696-z 2024-03-11 Nature Reviews Genetics 10.1038/s41576-024-00696-z https://www.nature.com/articles/s41576-024-00696-z
<![CDATA[Genetics of chronic respiratory disease]]> https://www.nature.com/articles/s41576-024-00695-0 Nature Reviews Genetics, Published online: 06 March 2024; doi:10.1038/s41576-024-00695-0

In this Review, Sayers et al. summarize findings from recent large-scale genetic epidemiology studies on the genetic underpinnings of chronic respiratory diseases. Furthermore, they outline how insights gained from such studies can improve treatment approaches.]]>
Ian SayersCatherine JohnJing ChenIan P. Hall doi:10.1038/s41576-024-00695-0 Nature Reviews Genetics, Published online: 2024-03-06; | doi:10.1038/s41576-024-00695-0 2024-03-06 Nature Reviews Genetics 10.1038/s41576-024-00695-0 https://www.nature.com/articles/s41576-024-00695-0
<![CDATA[How ancient genes form animal body plans]]> https://www.nature.com/articles/s41576-024-00717-x Nature Reviews Genetics, Published online: 04 March 2024; doi:10.1038/s41576-024-00717-x

Hajk-Georg Drost recalls a 2010 publication that used a phylotranscriptomic approach to estimate the age of genes that contribute to the developmental transcriptome across animal species and inspired a subsequent study on the embryonic hourglass in plants.]]>
Hajk-Georg Drost doi:10.1038/s41576-024-00717-x Nature Reviews Genetics, Published online: 2024-03-04; | doi:10.1038/s41576-024-00717-x 2024-03-04 Nature Reviews Genetics 10.1038/s41576-024-00717-x https://www.nature.com/articles/s41576-024-00717-x
<![CDATA[Changes in cell-cycle rate drive diverging cell fates]]> https://www.nature.com/articles/s41576-024-00714-0 Nature Reviews Genetics, Published online: 01 March 2024; doi:10.1038/s41576-024-00714-0

Kate Galloway highlights a paper by Kueh et al., who showed that the cell cycle indirectly influences concentrations of the transcription factor PU.1 to stabilize cell-fate trajectories in mice.]]>
Kate E. Galloway doi:10.1038/s41576-024-00714-0 Nature Reviews Genetics, Published online: 2024-03-01; | doi:10.1038/s41576-024-00714-0 2024-03-01 Nature Reviews Genetics 10.1038/s41576-024-00714-0 https://www.nature.com/articles/s41576-024-00714-0