Top 10
The top ten charts the articles that have been downloaded most often, in HTML format, from the Nature Reviews Endocrinology website in recent weeks. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.
Top of pageNews and Views
Diabetes: Incidence of childhood type 1 diabetes: a worrying trend
Ronald C. W. Ma & Juliana C. N. Chan
doi:10.1038/nrendo.2009.180
Review
Nutritional programming of the metabolic syndrome
Michael E. Symonds, Sylvain P. Sebert, Melanie A. Hyatt & Helen Budge
doi:10.1038/nrendo.2009.195
Early foundations of the metabolic syndrome may be laid as a consequence of changes in dietary supply to the rapidly growing fetus and/or postnatal offspring. This review highlights fetal developmental plasticity in cellular homeostasis that may manifest in adult life as the metabolic syndrome particularly if followed by a period of accelerated postnatal growth.
Research Highlight
Bone: Vitamin D deficiency implicated in bone mineralization defects
Vicky Heath
doi:10.1038/nrendo.2009.183
News and Views
Obesity: Calories or content: what is the best weight-loss diet?
Jonathan Q. Purnell
doi:10.1038/nrendo.2009.145
Research Highlight
Diabetes: Antipsychotic drugs and hyperglycemia risk in diabetes
Carol Wilson
doi:10.1038/nrendo.2009.185
Review
Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics
Robert H Lustig
doi:10.1038/ncpendmet0220
This Review examines the biochemistry that underlies the behaviors of obesity, in particular the relationship between hyperinsulinemia and leptin resistance. Hyperinsulinemia promotes the behaviors of increased calorie intake, decreased exercise and altered hedonic reward responses to food that are associated with the current obesity epidemic.
Review
Mechanisms of macrophage activation in obesity-induced insulin resistance
Justin I Odegaard & Ajay Chawla
doi:10.1038/ncpendmet0976
Macrophages have important roles in the complex relationship between obesity, inflammation and insulin resistance that are determined by whether they are classically or alternatively activated by T-helper-1 or T-helper-2 cytokines, respectively. The former leads to insulin resistance and the latter to protection against this condition. This Review discusses this crosstalk between the immune and metabolic systems.
Research Highlight
Obesity: Can genetic susceptibility to obesity be overcome?
Carol Wilson
doi:10.1038/nrendo.2009.171
Research Highlight
Obesity: Overweight as a risk factor for dementia
Rosanne Diaz
doi:10.1038/nrendo.2009.168
Research Highlight
Diabetes: Glucose levels and adverse pregnancy outcomes
Carol Wilson
doi:10.1038/nrendo.2009.163
