Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Obesity

Fat from plastics? Linking bisphenol A exposure and obesity

The weight of evidence indicates that bisphenol A (BPA), a widespread endocrine disruptor, might be an important risk factor for obesity and metabolic disorders. An epidemiological study shows an association between urinary BPA levels and increased body mass in children and adolescents.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Potential effects of BPA exposure during different stages of development.

References

  1. Speakman, R. J. & O'Rahilly, S. Fat: an evolving issue. Dis. Model. Mech. 5, 569–573 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Newbold, R. R., Padilla-Banks, E., Jefferson, W. N. & Heindel, J. J. Effects of endocrine disruptors on obesity. Int. J. Androl. 31, 201–208 (2008).

    Article  CAS  PubMed  Google Scholar 

  3. Trasande, L., Attina T. M. & Blustein J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA 308, 1113–1121 (2012).

    Article  CAS  PubMed  Google Scholar 

  4. Alonso-Magdalena, P., Quesada, I. & Nadal, A. Endocrine disruptors in the etiology of type 2 diabetes mellitus. Nat. Rev. Endocrinol. 7, 346–353 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Soriano, S. et al. Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β. PLoS ONE 7, e31109 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. vom Saal, F. S., Nagel, S. C., Coe, B. L., Angle, B. M. & Taylor J. A. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol. Cell. Endocrinol. 354, 74–84 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Carwile, J. L. and Michels, K. B. Urinary bisphenol A and obesity: NHANES 2003–2006. Environ. Res. 111, 825–830 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Shankar, A., Teppala, S. & Sabanayagam, C. Urinary bisphenol A levels and measures of obesity: results from the national health and nutrition examination survey 2003–2008. ISRN Endocrinol. 2012, 965243 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wang, T. et al. Urinary bisphenol A (BPA) concentration associates with obesity and insulin resistance. J. Clin. Endocrinol. Metab. 97, E223–E227 (2012).

    Article  CAS  PubMed  Google Scholar 

  10. Klimentidis, Y. C. et al. Canaries in the coal mine: a cross-species analysis of plurality of obesity epidemics. Proc. Biol. Sci. 278, 1626–1632 (2011).

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nadal, A. Fat from plastics? Linking bisphenol A exposure and obesity. Nat Rev Endocrinol 9, 9–10 (2013). https://doi.org/10.1038/nrendo.2012.205

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrendo.2012.205

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing