MEN1 is a syndrome with a complex nature and specific international clinical practice guidelines outlining standards of care have been developed. Genetic testing is recommended for patients with MEN1 and their families; however, the ethical, social, psychological and financial implications of such tests should be taken into account.
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References
Lips, C. J. M., Dreijerink, K. M. A., Links, T. P. & Höppener, J. W. M. Recent results of basic and clinical research in MEN1: opportunities to improve early detection and treatment. Expert Rev. Endocrinol. Metab. 7, 331–344 (2012).
Thakker, R. V. et al. Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1). J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2012-1230.
Eddy, D. M. et al. Individualized guidelines: the potential for increasing quality and reducing costs. Ann. Intern. Med. 154, 627–634 (2011).
Deresinski, S. & File, T. M. Jr. Improving clinical practice guidelines—the answer is more clinical research. Arch. Intern. Med. 171, 1402–1403 (2011).
Hill, J., Bullock, I. & Alderson, P. A summary of the methods that the National Clinical Guideline Centre uses to produce clinical guidelines for the National Institute for Health and Clinical Excellence. Ann. Intern. Med. 154, 752–757 (2011).
Suthers, G. K, Armstrong, J., McCormack J. & Trott, D. Letting the family know: balancing ethics and effectiveness when notifying relatives about genetic testing for a familial disorder. J. Med. Genet. 43, 665–670 (2006).
Forrest, L. E., Burke, J., Bacic, S. & Amor, D. J. Increased genetic counseling support improves communication of genetic information in families. Genet. Med. 10, 167–172 (2008).
Lucassen, A. & Parker, M. Confidentiality and sharing genetic information with relatives. Lancet 375, 1507–1509 (2010).
Mendes, A. & Sousa, L. Families' experience of oncogenetic counselling: accounts from a heterogeneous hereditary cancer risk population. Fam. Cancer 11, 291–306 (2012).
Lips, C. J. et al. Clinical screening as compared with DNA analysis in families with multiple endocrine neoplasia type 2A. N. Engl. J. Med. 331, 828–835 (1994).
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Lips, C., Höppener, J. Genetic testing for MEN1—whose responsibility?. Nat Rev Endocrinol 8, 575–576 (2012). https://doi.org/10.1038/nrendo.2012.164
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DOI: https://doi.org/10.1038/nrendo.2012.164
