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Editorial

Nature Reviews Endocrinology 4, 1 (1 January 2008) | doi:10.1038/ncpendmet0703

Resistance to thyroid hormone: one of several defects causing reduced sensitivity to thyroid hormone

Samuel Refetoff

Forty years have elapsed since the first published description of partial refractoriness to thyroid hormone (TH) (Refetoff S et al. [1967] J Clin Endocrinol Metab 27: 279–294). The three affected children, born to consanguineous parents, manifested symptoms of TH insufficiency but had elevated blood levels of TH.