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Nature Reviews Endocrinology 4, 8–9 (1 January 2008) | doi:10.1038/ncpendmet0685

Desmopressin stimulation provides accurate differential diagnosis of Cushing's syndrome

Castinetti F et al. (2007) Desmopressin test during petrosal sinus sampling: a valuable tool to discriminate pituitary or ectopic ACTH-dependent Cushing's syndrome. Eur J Endocrinol 157: 271–277 The standard test for differentiating between pituitary and ectopic adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome is corticotropin-releasing hormone (CRH)-stimulated inferior petrosal sinus sampling (IPSS); however, the discriminatory power of this technique has been questioned.