G-forces in endocrinology

Aart Jan van der Lely

doi:10.1038/ncpendmet0564 | Full Text | PDF (122K)

Dopaminergic treatment of nonfunctioning pituitary adenomas

Yona Greenman

Transsphenoidal surgery is the first-line treatment for non-functioning pituitary adenomas (NFPA); however, optimal management of residual tumor after surgery remains actively debated. Although dopamine agonists do not promote appreciable tumor shrinkage in NFPA, the author of this Viewpoint suggests that these agents could be used to prevent tumor re-enlargement.

doi:10.1038/ncpendmet0558 | Full Text | PDF (164K)

Will leptin become the treatment of choice for functional hypothalamic amenorrhea?

Corrine K Welt

Functional hypothalamic amenorrhea is associated with low levels of leptin, consistent with a state of energy deprivation. The author of this Viewpoint discusses whether administration of recombinant human leptin could replace the nutrition and behavioral interventions that are currently the treatment of choice for this disorder.

doi:10.1038/ncpendmet0561 | Full Text | PDF (160K)

Radioiodine treatment and mortality in patients with hyperthyroidism

doi:10.1038/ncpendmet0538 | Full Text | PDF (107K)

Genetic variant associated with BMI and adiposity

doi:10.1038/ncpendmet0539 | Full Text | PDF (107K)

Nonmelanoma skin cancer is associated with a lower risk of osteoporotic fractures

doi:10.1038/ncpendmet0540 | Full Text | PDF (119K)

Diabetes treatment and severe hypoglycemic events do not affect cognitive function

doi:10.1038/ncpendmet0541 | Full Text | PDF (109K)

Stem cell therapy for type 1 diabetes mellitus

doi:10.1038/ncpendmet0542 | Full Text | PDF (119K)

Educating parents might help to manage childhood overweight

doi:10.1038/ncpendmet0543 | Full Text | PDF (109K)

Effects of reconstituted HDL cholesterol infusions on measurements of atherosclerosis

doi:10.1038/ncpendmet0544 | Full Text | PDF (109K)

Increased BMI and the risk of incident disability in elderly people

doi:10.1038/ncpendmet0545 | Full Text | PDF (109K)

Thyroid hormone use does not lead to increased mortality in older women

doi:10.1038/ncpendmet0546 | Full Text | PDF (109K)

Sonoelastography can diagnose cervical lymph-node metastasis with high accuracy

doi:10.1038/ncpendmet0547 | Full Text | PDF (119K)

Torcetrapib treatment does not reduce atherosclerotic vascular disease

doi:10.1038/ncpendmet0548 | Full Text | PDF (108K)

Lowering salt intake reduces cardiovascular risk, as well as decreasing blood pressure

doi:10.1038/ncpendmet0549 | Full Text | PDF (120K)

Potential therapeutic target to improve cardiac function is a mediator of T₃ signaling

doi:10.1038/ncpendmet0550 | Full Text | PDF (109K)

Extended hypoestrogenicity negates the neuroprotective effect of estrogen therapy

doi:10.1038/ncpneuro0510 | Full Text | PDF (109K)

Does the use of proton-pump inhibitors increase the risk of fracture?

Bart L Clarke and Shreyasee Amin

doi:10.1038/ncpendmet0556 | Full Text | PDF (136K)

Does addition of gabapentin to antidepressant therapy improve control of hot flashes?

JoAnn V Pinkerton

doi:10.1038/ncpendmet0557 | Full Text | PDF (137K)

Can self-monitoring of foot temperature help prevent recurrence of diabetic foot ulcers?

John M Embil

doi:10.1038/ncpendmet0555 | Full Text | PDF (134K)

Can high bone turnover markers identify osteopenic postmenopausal women at risk of future fracture?

David M Reid

doi:10.1038/ncpendmet0560 | Full Text | PDF (137K)

Does addition of vildagliptin to metformin monotherapy improve glycemic control in patients with type 2 diabetes mellitus?

Ravi Retnakaran

doi:10.1038/ncpendmet0552 | Full Text | PDF (139K)

Drug Insight: breast cancer prevention and tissue-targeted hormone replacement therapy

Fernand Labrie

Selective estrogen-receptor modulators (SERMs) improve survival in women with breast cancer. There is, however, a need for more-effective SERMs and, most importantly, tissue-targeted alternatives to classical hormone replacement therapy while preventing breast cancer. This article describes how combining a SERM and dehydroepiandrosterone might prevent breast and uterine cancers, while benefiting other tissues affected by the menopause.

doi:10.1038/ncpendmet0559 | Full Text | PDF (503K)

Technology Insight: microarrays—research and clinical applications

Gregory Vlacich, Cheryl Roe and Gene C Webb

Microarray technology is well established as a research tool, and now it is increasingly being used in clinical and diagnostic settings. This article describes the principles behind microarrays, and details the current and potential applications in the search for biomarkers for diabetes, endocrine tumors and hormonal modulators of tumors.

doi:10.1038/ncpendmet0580 | Full Text | PDF (555K)