Table of contents
July 2007 Volume 3 No 7
Editorial
Viewpoints
The estrogen paradox
496Data from clinical trials have suggested that short-term treatment with estrogen (<10 years) results in a reduced incidence of breast cancer, whereas long-term treatment (>20 years) is associated with an increased risk of breast cancer. The authors of this Viewpoint describe possible mechanisms to account for these seemingly paradoxical effects.
The metabolic syndrome as a risk factor in simultaneous kidney–pancreas transplantation
498Simultaneous kidney–pancreas transplantation (SKPT) is the preferred treatment for patients with diabetes and end-stage diabetic nephropathy. Both immunologic and non-immunologic factors can affect patient outcome after SKPT. In this Viewpoint, the role of the metabolic syndrome as a risk factor for chronic renal transplant dysfunction is discussed.
Research Highlights
Bone architecture alterations assessed by CT aid prediction of fragility fracture
500Diagnosis of GH insufficiency requires two GH stimulation tests
500Morbidity and mortality associated with adipsic diabetes insipidus
500Patients with invasive macroprolactinomas might have undiagnosed epilepsy
501Highly potent PPAR-
agonist versus standard therapy in patients with lipid disorders
502Use of CXCL10 levels to predict thyroid autoimmunity following IFN- therapy
502Bloodspot sampling is suitable for monitoring cortisol levels in ACTH-deficient children
503Annual zoledronic acid infusion prevents bone loss in hypogonadal men
503Rosuvastatin slows intima–media thickening in individuals with subclinical atherosclerosis
503Fracture risk is increased in patients with atrial fibrillation or receiving amiodarone
504Hydrochlorothiazide has a beneficial and durable effect on BMD in postmenopausal women
504Intragastric botulinum toxin injections can be used to treat morbid obesity
505Practice Points
A comparison of classification schemes for ketosis-prone diabetes
506Growth hormone as an anti-aging therapy—do the benefits outweigh the risks?
508Can serum thyroglobulin levels predict patient outcome after treatment of differentiated thyroid carcinoma?
510Ovulation induction in polycystic ovary syndrome—how do metformin and clomifene citrate compare?
512Pegvisomant for the treatment of acromegaly—translation of clinical trials into clinical practice
514Reviews
The role of physical activity in producing and maintaining weight loss
518This article reviews the role of physical activity in producing and maintaining weight loss. The focus is on prospective randomized controlled trials; however, other prospective trials, meta-analyses and large systematic reviews are included. The limitations of the current body of literature are identified and discussed, and future research directions suggested.
doi:10.1038/ncpendmet0554 | Full Text | PDF (301K)
Mechanisms of Disease: lessons from ethnicity in the role of triglyceride metabolism in ischemic heart disease
530Examination of triglyceride metabolism and lipoprotein profiles in different ethnic groups reveals a range of potential risk factors for heart disease, especially when related to conditions such as insulin resistance. Further study should allow greater understanding of the role of triglycerides in the development of, or protection from, heart disease.
doi:10.1038/ncpendmet0530 | Full Text | PDF (273K)
Mechanisms of Disease: the developmental origins of disease and the role of the epigenotype
539Epigenetic mechanisms alter gene expression without changing the nucleotide sequence; nevertheless, they can transmit through generations of cells. This article discusses how the fetal environment might affect the epigenotype of the fetus and how this might affect subsequent development of diseases, such as diabetes, later in life and perhaps in subsequent generations.
doi:10.1038/ncpendmet0531 | Full Text | PDF (286K)
Case Study
Diagnosis of primary aldosteronism in a patient with an incidentally found adrenal mass
547doi:10.1038/ncpendmet0553 | Full Text | PDF (212K)
