Nature Clinical Practice Endocrinology & Metabolism | Table 1 : The role of PET in follow-up of patients treated for differentiated epithelial thyroid cancers

From the following article:

The role of PET in follow-up of patients treated for differentiated epithelial thyroid cancers

Sophie Leboulleux, Pamela R Schroeder, Martin Schlumberger and Paul W Ladenson

Nature Clinical Practice Endocrinology & Metabolism (2007) 3, 112-121
doi:10.1038/ncpendmet0402

Study^{^a} (n of patients)	Patient characteristics	Range of ¹³¹I given/% with normal ¹³¹I TBS (n done)/% with raised anti-Tg Ab or Tg	Condition when PET performed	Neck imaging/chest CT in all patients?	Sensitivity (patient-based analysis)
^aPET was performed in all studies except Nahas et al.⁴⁵, Palmedo et al.⁴⁶, and Saab et al.⁴⁸ (who used PET–CT) and Pryma et al.⁴⁹ (who used PET or PET–CT).
^bAn elevated Tg level defined as level >1 g/l.
^cElevated Tg defined as >5 g/l.
^dElevated Tg defined as >2 g/l.
^e82% if Tg levels elevated and TBS normal.
^f87% in patients with Hürthle cell cancer and 85% in those with normal ¹³¹I TBS.
^g71% in patients with elevated Tg levels.
^h100% in patients with elevated Tg levels.
ⁱ100% in patients with abnormal CI.
Abbreviations: Ab, antibodies; CI, conventional imaging; DTC, differentiated thyroid cancer; LVT TX, during levothyroxine therapy; LVT WD, after levothyroxine withdrawal; NA, not available; rhTSH, recombinant human TSH; TBS, total-body scan; Tg, thyroglobulin; TX, therapy; US, ultrasonography.
Dietlein et al.¹⁸ (58)	Consecutive patients with DTC	1.1–11.1 GBq/71 (58)/62^{^b}	LVT WD	Yes (US and MRI)/no	50%^{^e}
Altenvoerde et al.²⁸ (12)	An elevated Tg level and normal ¹³¹I TBS, cervical US, abdominal US, and chest X-ray	0.5–3.0 GBq/100 (12)/100^{^b}	LVT WD (except one)	Yes/no	50%
Conti et al.²⁹ (24)	Patients with an elevated Tg level or a positive anti-Tg antibody test	NA/71 (17)/100^{^b}	LVT TX or LVT WD	No/no	100%
Grunwald et al.³⁰ (222)	Retrospective, multicenter study	Mean 3 GBq/75 (222)/48^{^c}	LVT TX or LVT WD	No/no	75%^{^f}
Stokkel et al.³¹ (11)	An elevated Tg level	7.4 GBq/91 (11)/100^{^b}	LVT TX	No/no	73%
Wang et al.³² (37)	Normal ¹³¹I TBS	0.07–0.20 GBq/100 (37)/70^{^b}	On rhTSH, LVT TX, or LVT WD	No/no	49%^{^g}
Alnafisi et al.³³ (11)	An elevated Tg level and normal ¹³¹I TBS	3.7–7.4 GBq/100 (11)/100^{^b}	LVT TX (except one)	Yes/Yes	100%
Muros et al.³⁴ (10)	An elevated Tg level, normal ¹³¹I TBS, and ²⁰¹Tl TBS	0.19 GBq/100 (10)/100^{^b}	LVT WD	No/no	60%
Frilling et al.⁸⁵ (24)	An elevated Tg level and normal ¹³¹I TBS	3–10 GBq/100 (24)/100^{^b}	NA	Yes (except one)/no	92%
Helal et al.³⁶ (37)	An elevated Tg level and normal ¹³¹I TBS	3.7 GBq/100 (37)/100^{^b}	LVT TX	Yes/no	76%
Schluter et al.³⁷ (64)	Patients with either an elevated Tg level or abnormal CI	NA/89 (64)/86^{^d}	LVT TX or LVT WD	NA/NA	69%
Plotkin et al.³⁸ (17)	Hürthle cell cancer and either an elevated Tg level or abnormal CI	NA/75 (11)/76^{^d}	LVT TX or LVT WD	Yes/no	82%^{^h}
Giammarile et al.⁴⁰ (51)	An elevated Tg level and normal ¹³¹I TBS	1.9–5.6 GBq/100 (51)/100^{^b}	LVT TX (except six)	Yes/no	67%
Goshen et al.⁴¹ (20)	An elevated Tg level and/or palpable neck findings	0.07–0.15 GBq /100 (20)/80^{^b}	On thyroxine or rhTSH	No/no	70%
Lowe et al.⁴² (12)	Hürthle cell cancer	NA/100 (7)/NA	NA	No/no	92%
Gabriel et al.⁴⁴ (36)	An elevated Tg level	NA/100 (36)/100^{^b}	LVT TX	Yes/yes	88%
Nahas et al.⁴⁵ (33)	An elevated Tg level and/or normal ¹³¹I TBS	NA/76 (33)/85^{^b}	NA	No/yes	66%
Palmedo et al.⁴⁶ (40)	An elevated Tg level or abnormal CI and normal ¹³¹I TBS	0.04–0.11 GBq/100 (40)/85^{^b}	LVT WD	No/no	45%
Alzahrani et al.⁴⁷ (50)	An elevated Tg level or abnormal CI	Median 5.5 GBq/100 (48)/84^{^d}	LVT WD	Yes/no	62%
Saab et al.⁴⁸ (15)	An elevated Tg level, normal neck US, and normal chest CT	3.7–7.4 GBq/100 (15)/100^{^b}	LVT WD or on rhTSH	Yes/yes	60%
Pryma et al.⁴⁹ (44)	Hürthle cell cancer	NA/79 (33)/NA	LVT TX (except two)	No/no	55%^ⁱ

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TABLE 1 Studies that investigated the sensitivity of 2-[18F]-fluoro-2-deoxyglucose PET for diagnosis of thyroid cancer recurrence and that included 10 patients or more.

From the following article:

The role of PET in follow-up of patients treated for differentiated epithelial thyroid cancers

PowerPoint slides for teaching

TABLE 1 Studies that investigated the sensitivity of 2-[¹⁸F]-fluoro-2-deoxyglucose PET for diagnosis of thyroid cancer recurrence and that included 10 patients or more.