Table of contents
December 2007 Volume 3 No 12
Editorial
Viewpoints
Health-related quality of life—an economist's perspective
786Health-related quality of life (HRQOL) is an index of the perceived effects of disease and therapy on the individual patient. HRQOL is a multi-dimensional concept and debate continues about the utility of generic versus disease-specific questionnaires for assessing HRQOL. The authors of this Viewpoint examine the position of the health economist in HRQOL analysis.
doi:10.1038/ncpendmet0650 | Full Text | PDF (115K)
Can fibroblast growth factor 23 fine-tune therapies for diseases of abnormal mineral ion metabolism?
788High serum fibroblast growth factor 23 (FGF-23) levels are associated with phosphaturia in several inherited and acquired human diseases. As FGF-23 actively regulates phosphate homeostasis, the author proposes that modulation of components of the FGF-23 signal transduction pathway might provide a novel therapeutic strategy for diseases of abnormal mineral ion metabolism.
doi:10.1038/ncpendmet0667 | Full Text | PDF (118K)
Research Highlights
The addition of sitagliptin improves glycemic control in patients with type 2 diabetes
790Highly sensitive thyroglobulin assay is useful in the follow-up of patients treated for DTC
790HRT increases cardiovascular risk when started many years after the menopause
790Bisphosphonates prevent accelerated bone loss in women treated with anastrozole
791Basal-bolus insulin regimen is effective for hospitalized patients with type 2 diabetes
791Factors influencing restaurant portion sizes and subsequent energy intake
792Parathyroidectomy improves BMD and quality-of-life in patients with asymptomatic PHPT
792Characterization of normocalcemic primary hyperparathyroidism
793Pediatric metabolic syndrome predicts CVD in later life
793Devising a nomogram to assess absolute risk of hip fracture
793Cinacalcet hydrochloride reduces hypercalcemia in patients with parathyroid carcinoma
794Shorter survival of SDHB mutation carriers with malignant pheochromocytomas
794Criteria for malignancy of lymph nodes on neck ultrasonography
795Practice Points
Is orbital decompression a safe and effective treatment for Graves' orbitopathy?
796doi:10.1038/ncpendmet0624 | Full Text | PDF (114K)
Does treatment with rosiglitazone increase cardiovascular risk of patients with type 2 diabetes mellitus?
798doi:10.1038/ncpendmet0640 | Full Text | PDF (115K)
Can biochemical markers discriminate between new-onset type 1 and type 2 diabetes mellitus in children?
800doi:10.1038/ncpendmet0642 | Full Text | PDF (116K)
Does insulin concentration modify the outcome of dietary intervention in young adults with obesity?
802doi:10.1038/ncpendmet0643 | Full Text | PDF (117K)
Thyroid late effects after treatment of childhood sarcoma
804doi:10.1038/ncpendmet0646 | Full Text | PDF (112K)
Is anti-inflammatory therapy for type 2 diabetes mellitus ready for routine clinical practice?
806doi:10.1038/ncpendmet0645 | Full Text | PDF (123K)
Does a comprehensive rehydration regimen reduce neurologic complications associated with diabetic ketoacidosis?
808doi:10.1038/ncpendmet0649 | Full Text | PDF (117K)
Reviews
Management approaches for pediatric obesity
810Obesity rates are increasing alarmingly in children and infants, with predictable but devastating consequences for health. This article outlines the causes for these increases and suggests strategies to prevent and treat childhood obesity. These include a systematic approach from pediatricians and input from the family, school and community.
doi:10.1038/ncpendmet0669 | Full Text | PDF (246K)
Therapy Insight: fertility in women after cancer treatment
819Thankfully, survival rates for cancer sufferers are improving all the time. One crucial issue affecting patients' quality of life is preservation or optimal enhancement of fertility, which can be compromised during treatment. This article outlines the impact of treatment, predictive markers of reproductive function and methods to prevent infertility among women.
doi:10.1038/ncpendmet0675 | Full Text | PDF (208K)
Technology Insight: small, noncoding RNA molecules as tools to study and treat endocrine diseases
827As detailed here, the discovery of small, interfering RNA molecules and their naturally occurring counterpart, micro-RNA molecules, has greatly influenced modern research and has also given new insights into endocrine diseases. Therapeutic applications of RNA interference have now reached the stage of clinical trials.
doi:10.1038/ncpendmet0674 | Full Text | PDF (232K)
Case Study
A patient with type B insulin resistance syndrome, responsive to immune therapy
835Immune-mediated insulin resistance should be considered in patients with increasing hyperglycemia despite high-dose insulin treatment. This article illustrates the differential diagnosis of insulin resistance and describes the features and management of the type B insulin resistance syndrome.
doi:10.1038/ncpendmet0693 | Full Text | PDF (213K)
Article Response
A comparison of classification schemes for ketosis-prone diabetes
E1doi:10.1038/ncpendmet0698 | Full Text
