Table of contents
November 2007 Volume 3 No 11
Diabetes and hypertension: inextricably linked
The treatment of diabetes and hypertension has become one of the greatest challenges for medical professionals today. It is estimated that by 2025 some 1.56 billion people will have hypertension and by 2030 around 366 million will have diabetes. From October 22nd 2007, Nature Clinical Practice will be presenting a selection of articles from a variety of Nature Publishing Group journals that will focus on these conditions.
Editorial
Viewpoints
Modified macronutrient diets and weight loss—are food choice and variety more important than caloric restriction?
728Limitation of caloric intake is often used to promote weight loss in overweight or obese individuals; however, this strategy can fail because of the associated increase in appetite and decrease in total daily energy expenditure. In this Viewpoint, an alternative approach to caloric restriction is discussed—the modified macronutrient diet.
doi:10.1038/ncpendmet0636 | Full Text | PDF (134K)
Diabetic ketoacidosis in type 2 diabetes mellitus—pathophysiology and clinical presentation
730Although diabetic ketoacidosis is considered a key clinical feature of type 1 diabetes mellitus, this phenomenon has become increasingly common in patients with type 2 diabetes mellitus. The authors of this Viewpoint examine the diagnostic criteria, precipitating causes, and pathogenesis of diabetic ketoacidosis associated with type 2 diabetes mellitus.
doi:10.1038/ncpendmet0641 | Full Text | PDF (137K)
Research Highlights
Positive association of Addison's disease with celiac disease
732Patients on sunitinib should be monitored for hypothyroidism
732doi:10.1038/ncpendmet0606 | Full Text | PDF (101K)
Risedronate reduces BMD loss after hip replacement
732Mutation type does not predict tumor penetrance in multiple endocrine neoplasia type 1
733Type 2 diabetes and hyperglycemia increase mortality in patients with pneumonia
733doi:10.1038/ncpendmet0608 | Full Text | PDF (101K)
Fluoride increases BMD but also increases risk of osteomalacia
734Serum total inhibin assay shows good results for detecting epithelial ovarian cancer
734doi:10.1038/ncpendmet0628 | Full Text | PDF (100K)
Antidepressants and traditional anticonvulsants are best for diabetic neuropathic pain
734Growth hormone can prevent height loss in patients with JIA
735Endocrine function should be evaluated in patients with Fanconi anemia
735doi:10.1038/ncpendmet0630 | Full Text | PDF (100K)
BMD recovery after nutritional rehabilitation and return of menses in anorexic patients
736QRISK: a new British cardiovascular disease risk algorithm
737Practice Points
An evaluation of serum thyroglobulin assays for the detection of recurrent differentiated thyroid carcinoma
738doi:10.1038/ncpendmet0617 | Full Text | PDF (138K)
Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy
740doi:10.1038/ncpendmet0619 | Full Text | PDF (137K)
Body mass index as a risk factor for incident hypertension
742doi:10.1038/ncpendmet0622 | Full Text | PDF (138K)
An assessment of biochemical tests for the diagnosis of pheochromocytoma
744doi:10.1038/ncpendmet0615 | Full Text | PDF (138K)
Is parathyroid hormone (1–84) a safe and effective treatment for postmenopausal osteoporosis?
746doi:10.1038/ncpendmet0626 | Full Text | PDF (137K)
Reviews
Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias
748Bilateral adrenocortical hyperplasias (BAHs) are one cause of adrenocorticotropin-independent Cushing's syndrome. Until recently BAHs were relatively unknown and thought to be infrequent. This article reviews the molecular genetics of adrenocortical tumor development with an emphasis on BAHs. It also suggests a classification for BAHs that is based on their genetics and histology.
doi:10.1038/ncpendmet0648 | Full Text | PDF (633K)
The replication of 
cells in normal physiology, in disease and for therapy
758Replication of 
cells is important in childhood expansion of -cell mass, and offers a potential therapeutic strategy for diabetes. As discussed here, however, mechanisms of increased -cell mass in adulthood in humans are not well understood, and the influence of mechanisms such as apoptosis might interfere with therapeutic approaches.
doi:10.1038/ncpendmet0647 | Full Text | PDF (629K)
Technology Insight: detecting growth hormone abuse in athletes
769Although its performance-enhancing effects remain unclear, athletes are thought to be doping themselves with recombinant human growth hormone, which is banned by regulatory authorities for this context. This article describes the challenges faced in designing test methods to detect this abuse, and details the assays that are currently in use or development.
doi:10.1038/ncpendmet0644 | Full Text | PDF (318K)
Case Study
Cushing's syndrome in women with polycystic ovaries and hyperandrogenism
778Women with Cushing's syndrome are often misdiagnosed as having polycystic ovarian syndrome. The authors highlight the importance of correctly diagnosing the two disorders and describe the clinical features and investigations that can help to distinguish them.
doi:10.1038/ncpendmet0665 | Full Text | PDF (293K)
