Table of contents
January 2007 Volume 3 No 1
Viewpoints
Islet transplantation for type 1 diabetes—where should we go?
2Although the success rate of islet transplantation for patients with type 1 diabetes has improved, many issues still need to be resolved. In this Viewpoint, the authors highlight areas of concern, including the inefficiency of current isolation protocols and the occurrence of adverse events, and ask how the efficacy of this procedure can be enhanced.
Severe iatrogenic hypoglycemia in type 2 diabetes mellitus
4Hypoglycemia-associated autonomic failure (HAAF) describes the syndromes of defective glucose regulation and hypoglycemia unawareness. Originally characterized in type 1 diabetes, the author of this Viewpoint suggests that HAAF is also a component of iatrogenic hypoglycemia in patients with type 2 diabetes, and represents a barrier to glycemic control.
Research Highlights
Rosiglitazone, but not ramipril, prevents onset of type 2 diabetes in high-risk patients
6Insulin-independence is rarely sustained after pancreatic islet transplantation
6New protocols for the management of hyperglycemia in hospitalized patients
7Practice Points
Are antihypertensive drugs associated with an increased risk of incident type 2 diabetes?
8Clinical and public health implications of glycemic relapse in type 2 diabetes
10Reviews
The neuropathic diabetic foot
14Foot problems are a very common complication of type 1 and type 2 diabetes. Most are neuropathic in origin and should be preventable. This Review details preventative strategies, and the many monitoring and treatment options currently available, for a condition that has major consequences for patients and health-care providers.
doi:10.1038/ncpendmet0347 | Full Text | PDF (390K)
The changing costs and benefits of screening for asymptomatic coronary heart disease in patients with diabetes
26This Review examines the pros and cons of screening for coronary heart disease in asymptomatic subjects with diabetes. At present, there is insufficient evidence of clinical benefit to justify such a practice; therefore, carefully conducted clinical trials are urgently required to resolve the question.
doi:10.1038/ncpendmet0352 | Full Text | PDF (270K)
Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners
36Fulminant type 1 diabetes appears to a disease subtype that features a characteristic range of clinical symptoms, with extremely rapid onset, and thus must be treated very quickly. It is currently prevalent in Japan, and might be associated with particular genotypes and possibly with viral infection.
doi:10.1038/ncpendmet0351 | Full Text | PDF (309K)
Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes
46Endothelial dysfunction occurs commonly in diabetes and insulin resistance. This Review describes mechanisms that promote development of atherosclerosis in these conditions through changes in endothelial cell signaling and function. Such mechanisms might be drug targets, and endothelium-dependent vasodilation and other tests could be used to monitor the efficacy of interventions.
doi:10.1038/ncpendmet0366 | Full Text | PDF (295K)
Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates
57Hyperinsulinism is the single commonest cause of hypoglycemia in infants. This Review describes the five known mutations that cause congenital hyperinsulinism, and the other forms of hyperinsulinism. It also details the diagnostic approach and treatment options, emphasizing the need for a multidisciplinary approach.
doi:10.1038/ncpendmet0368 | Full Text | PDF (574K)
Corrigendum
Cushing's syndrome caused by an occult source: difficulties in diagnosis and management
69doi:10.1038/ncpendmet0387 | Full Text | PDF (125K)
