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Nature Reviews Endocrinology 2, 64–65 (1 February 2006) | doi:10.1038/ncpendmet0089

Obesity-related insulin resistance is reversible after weight loss

Rebecca Doherty

L|[ouml]|fgren P et al. (2005) Prospective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction. Diabetologia 48: 2334–2342 Obesity is characterized by an increase in the number (hyperplasia) and size (hypertrophy) of adipocytes, and by insulin and catecholamine resistance.