TABLE 2  Signs and symptoms of Cushing syndrome.

From the following article:

Difficulty in the diagnosis of Cushing disease

Lynnette K Nieman

Nature Clinical Practice Endocrinology & Metabolism (2006) 2, 53-57
doi:10.1038/ncpendmet0074

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Signs and symptoms% patientsa

aThe percentage of 70 patients with Cushing syndrome who experienced each of the signs and symptoms listed. Modified with permission from reference 15 © (1982) Elsevier Limited. ECG, electrocardiogram.

Decreased libido (men/women)100
Obesity or weight gain97
Plethora94
Round face88
Menstrual changes84
Hirsutism81
Hypertension74
Ecchymoses62
Lethargy, depression62
Striae (especially if >1 cm, purple)56
Weakness (especially proximal)56
ECG changes or atherosclerosis55
Dorsal fat pad54
Edema50
Abnormal glucose tolerance50
Osteopenia or fracture50
Headache47
Backache43
Recurrent infections25
Abdominal pain21
Acne21
Female balding13

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