The osteosarcoma genome has long been known to be complex, with few common features between tumours. However, a growing number of somatic genome studies, including a recent study by Behjati et al., have identified common themes in subsets of these cancers. The data suggest that subsets of somatic signatures could be therapeutically tractable targets.
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Acknowledgements
The authors' work is supported by the intramural research program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute.
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Savage, S., Mirabello, L. Is the osteosarcoma genome targetable?. Nat Rev Endocrinol 13, 506–508 (2017). https://doi.org/10.1038/nrendo.2017.101
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DOI: https://doi.org/10.1038/nrendo.2017.101
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