A recent study by Clayton et al. shows that overall mortality is increased for patients with Cushing disease, even in remission, but that mortality is normal if long-term remission is induced by only one pituitary surgery. These findings emphasize the importance of expert pituitary surgery.
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References
Lacroix, A., Feelders, R. A., Stratakis, C. A. & Nieman, L. K. Cushing's syndrome. Lancet 386, 913–927 (2015).
Newell-Price, J., Bertagna, X., Grossman, A. B. & Nieman, L. K. Cushing's syndrome. Lancet 367, 1605–1617 (2006).
Pivonello, R. et al. Complications of Cushing's syndrome: state of the art. Lancet Diabetes Endocrinol. 4, 611–629 (2016).
Clayton, R. N. et al. Mortality in patients with Cushing's disease more than 10 years after remission: a multicentre, multinational, retrospective cohort study. Lancet Diabetes Endocrinol. 4, 569–576 (2016).
Nieman, L. K. et al. Treatment of Cushing's syndrome: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 100, 2807–2831 (2015).
Plotz, C. M., Knowlton, A. I. & Ragan, C. The natural history of Cushing's syndrome. Am. J. Med. 13, 597–614 (1952).
Ross, E. J. & Linch, D. C. Cushing's syndrome — killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet 2, 646–649 (1982).
van Haalen, F. M., Broersen, L. H., Jorgensen, J. O., Pereira, A. M. & Dekkers, O. M. Management of endocrine disease: mortality remains increased in Cushing's disease despite biochemical remission: a systematic review and meta-analysis. Eur. J. Endocrinol. 172, R143–R149 (2015).
Bergthorsdottir, R., Leonsson-Zachrisson, M., Oden, A. & Johannsson, G. Premature mortality in patients with Addison's disease: a population-based study. J. Clin. Endocrinol. Metab. 91, 4849–4853 (2006).
Sherlock, M. et al. ACTH deficiency, higher doses of hydrocortisone replacement, and radiotherapy are independent predictors of mortality in patients with acromegaly. J. Clin. Endocrinol. Metab. 94, 4216–4223 (2009).
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The author has received consultancy fees and research support from HRA Pharma, Ipsen and Novartis Pharmaceuticals.
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Newell-Price, J. Mortality in Cushing disease. Nat Rev Endocrinol 12, 502–503 (2016). https://doi.org/10.1038/nrendo.2016.118
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DOI: https://doi.org/10.1038/nrendo.2016.118
