Integrated genome-wide methylation and gene expression profiling of aldosteronomas (n = 25), normal adrenal cortical tissue (n = 10) and nonfunctioning adrenocortical tumors (n = 13) has determined that altered methylation in aldosteronomas is associated with dysregulated expression of genes involved in steroid biosynthesis. Specifically, AVPR1A and PRKCA were downregulated and hypermethylated, and CYP11B2 was upregulated and hypomethylated in aldosteronomas.
References
Howard, B. et al. Integrated analysis of genome-wide methylation and gene expression shows epigenetic regulation of CYP11B2 in aldosteronomas. J. Clin. Endocrinol. Metab. 10.1210/jc.2013-3495
Rights and permissions
About this article
Cite this article
Epigenetic regulation of steroid biosynthesis gene expression in aldosteronomas. Nat Rev Endocrinol 10, 128 (2014). https://doi.org/10.1038/nrendo.2013.269
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrendo.2013.269