Treatment with 1,25-dihydroxyvitamin D3 (1,25[OH]2 D3) suppresses leptin-mediated growth of ovarian cancer cells and administration of a 1,25(OH)2 D3 analogue suppresses ovarian tumour growth induced by a high-fat diet in mice, show new findings. The anti-leptin effects of 1,25(OH)2 D3 are mediated by a microRNA, miR-498, which downregulates expression of telomerase reverse transcriptase mRNA.
References
Kasiappan, R. et al. Vitamin D suppresses leptin stimulation of cancer growth through microRNA. Cancer Res. 10.1158/0008-5472.CAN-14-1702
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MicroRNA-mediated effects of vitamin D on leptin-stimulated tumour growth. Nat Rev Endocrinol 10, 702 (2014). https://doi.org/10.1038/nrendo.2014.179
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DOI: https://doi.org/10.1038/nrendo.2014.179
