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Nature Reviews Endocrinology 1, 69 (1 December 2005) | doi:10.1038/ncpendmet0044

Early hyperinsulinemia predicts gestational diabetes mellitus in high-risk patients

Carol Lovegrove

Bit|[oacute]|T et al. (2005) Prediction of gestational diabetes mellitus in a high-risk group by insulin measurement in early pregnancy. Diabet Med 22: 1434–1439 Increased insulin production during pregnancy is a response to the twofold to threefold increase in insulin requirements, which begins at around 16–18 weeks of gestation.