Insights from the ENDO 2005 meeting

P Reed Larsen

doi:10.1038/ncpendmet0050 | Full Text | PDF (53K)

Do all patients with RET mutations associated with multiple endocrine neoplasia type 2 require surgery?

Diana L Learoyd and Bruce G Robinson

Screening for mutations in the RET proto-oncogene has revolutionized management of multiple endocrine neoplasia type 2 (MEN2), although controversy still exists regarding the timing and extent of surgical intervention. This Viewpoint discusses the relationship between genotype and phenotype in MEN2 and describes strategies to determine the appropriate age for patients to undergo thyroidectomy.

doi:10.1038/ncpendmet0045 | Full Text | PDF (76K)

Management of patients with glucocorticoid deficiency

Anna Crown and Stafford Lightman

At present, patients with hypoadrenalism are treated with hydrocortisone replacement regimens which aim to mimic the natural circadian rhythms of glucocorticoid secretion. As current knowledge regarding glucocorticoid biology increases, however, it is becoming clear that replacement therapies are nonphysiologic and could affect patients' quality of life.

doi:10.1038/ncpendmet0051 | Full Text | PDF (78K)

Co-administration of gut hormones suppresses appetite

Vicky Heath

doi:10.1038/ncpendmet0031 | Full Text | PDF (63K)

Continuous subcutaneous insulin infusion improves glycemic control and quality of life in type 1 diabetes

Carol Lovegrove

doi:10.1038/ncpendmet0032 | Full Text | PDF (62K)

Decreased risk of diabetes in coffee and tea drinkers

Marie Lofthouse

doi:10.1038/ncpendmet0033 | Full Text | PDF (73K)

Ghrelin and food intake in obese and lean individuals

Marie Lofthouse

doi:10.1038/ncpendmet0034 | Full Text | PDF (65K)

Decreased late luminal loss associated with sirolimus-eluting versus paclitaxel-eluting stents

Carol Lovegrove

doi:10.1038/ncpendmet0035 | Full Text | PDF (73K)

A single infusion of zoledronic acid is safe and effective for the treatment of Paget's disease

Marie Lofthouse

doi:10.1038/ncpendmet0036 | Full Text | PDF (64K)

Hypertension in patients with acromegaly

Caroline Barranco

doi:10.1038/ncpendmet0037 | Full Text | PDF (64K)

Long-term impact of subclinical postpartum thyroiditis

Rebecca Doherty

doi:10.1038/ncpendmet0038 | Full Text | PDF (64K)

Leptin levels predict features of the metabolic syndrome

Marie Lofthouse

doi:10.1038/ncpendmet0039 | Full Text | PDF (64K)

ED-71: a promising new candidate for the treatment of osteoporosis?

Carol Lovegrove

doi:10.1038/ncpendmet0040 | Full Text | PDF (73K)

Arterial structure and endothelial function in Turner syndrome

Carol Lovegrove

doi:10.1038/ncpendmet0041 | Full Text | PDF (64K)

Testosterone patch increases sexual activity in women with hypoactive sexual desire disorder

Marie Lofthouse

doi:10.1038/ncpendmet0042 | Full Text | PDF (73K)

Depot medroxyprogesterone acetate for contraception causes weight and fat gain in women

Marie Lofthouse

doi:10.1038/ncpendmet0043 | Full Text | PDF (64K)

Early hyperinsulinemia predicts gestational diabetes mellitus in high-risk patients

Carol Lovegrove

doi:10.1038/ncpendmet0044 | Full Text | PDF (64K)

Does exenatide provide a meaningful new treatment option for patients with type 2 diabetes?

Daniel J Drucker

doi:10.1038/ncpendmet0026 | Full Text | PDF (79K)

Can drospirenone with 17- estradiol safely reduce blood pressure in hypertensive postmenopausal women?

Adam Whaley-Connell, John Palmer and James R Sowers

doi:10.1038/ncpendmet0029 | Full Text | PDF (82K)

Is alendronate therapy cost-effective for postmenopausal osteopenia?

E Michael Lewiecki

doi:10.1038/ncpendmet0052 | Full Text | PDF (77K)

Does pregnancy-induced hypertension increase the risk of developing metabolic syndrome?

Kavitha Ram and Nanette Santoro

doi:10.1038/ncpendmet0053 | Full Text | PDF (78K)

Is pamidronate effective in preventing chemotherapy-induced bone loss?

Charles L Shapiro

doi:10.1038/ncpendmet0048 | Full Text | PDF (77K)

Intensive insulin therapy regimens: is there a difference in patient satisfaction?

Barry J Goldstein

doi:10.1038/ncpendmet0054 | Full Text | PDF (78K)

Long-term risks for thyroid cancer and other neoplasms after exposure to radiation

Arthur B Schneider and David H Sarne

Radiation is still used to treat childhood malignancies, and many individuals have in the past been exposed to external radiation. The various risk factors, incidence rates and characteristics of thyroid cancer and other neoplasms after exposure to low-dose radiation are becoming clearer, as are screening and treatment strategies.

doi:10.1038/ncpendmet0022 | Full Text | PDF (157K)

Mechanisms of Disease: selective inhibition of 11-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

Jeremy W Tomlinson and Paul M Stewart

Isoenzymes of 11[beta]-hydroxysteroid dehydrogenase affect the tissue-specific interconversion of cortisone and cortisol. In rodents, selective inhibitors of these enzymes improve insulin sensitivity, and we await clinical trials to test whether such drugs can be "magic bullets" to treat type 2 diabetes and the metabolic syndrome.

doi:10.1038/ncpendmet0023 | Full Text | PDF (241K)

Mechanisms of Disease: pathway-selective insulin resistance and microvascular complications of diabetes

Per-Henrik Groop, Carol Forsblom and Merlin C Thomas

Diabetes and obesity are associated with pathway-selective insulin resistance in the phosphatidylinositol 3-kinase and CBL E3 ubiquitin protein ligase–(CBL)/CBL E3 ubiquitin protein ligase associated protein (CAP) signaling pathways, while insulin signaling via extracellular signal-regulated kinase (ERK) is comparatively unaffected, tipping the balance of insulin's actions so that they favor abnormal vasoreactivity, angiogenesis, and other pathways implicated in the development and progression of microvascular disease.

doi:10.1038/ncpendmet0046 | Full Text | PDF (326K)