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Polycystic ovary syndrome (PCOS) is a major public health problem affecting ~11–13% of women worldwide. In this Primer, Stener-Victorin et al. review the epidemiology and pathophysiology of PCOS and highlight the latest advances in the diagnosis and management of this syndrome.
Gastric neuroendocrine neoplasms (gNENs) are rare tumours of the neuroendocrine cells of the stomach and consist of different subtypes with distinct management and prognosis. In this Primer, Campana and colleagues review the complex biology of the various gNEN subtypes and their epidemiology, diagnosis and management, and highlight the unmet needs in the field.
This PrimeView highlights the epidemiology of multidrug-resistant tuberculosis, and summarizes the mechanisms, diagnosis and management of this disease. It accompanies the Primer article on this topic by Dheda et al.
Multidrug-resistant tuberculosis (MDR-TB) is caused by Mycobacterium tuberculosis that is resistant to several first-line drugs. MDR-TB is an increasing public health challenge. In this Primer, Dheda et al. summarize the epidemiology and mechanisms, and discuss diagnosis, management and quality of life of patients with MDR-TB.
This PrimeView highlights the diagnosis of invasive candidiasis, and summarizes its epidemiology, mechanisms and management. It accompanies the Primer article on this topic by Lass- Flörl et al.
Invasive candidiasis is a fungal disease caused by Candida pathogens. In this Primer, Lass-Flörl et al. summarize current knowledge of epidemiology and mechanisms and discuss the diagnosis, treatment and quality of life of patients with invasive candidiasis. They also highlight outstanding research questions.
This PrimeView highlights the mechanisms that lead to retinal detachment, and summarizes the epidemiology, diagnosis and management of this disorder. It accompanies the Primer article on this topic by Lin et al.
Retinal detachment describes the separation of the neurosensory retina from the underlying retinal pigment epithelium, leading to impaired vision or vision loss. This Primer discusses the epidemiology, pathophysiology, diagnosis and management of this disorder and highlights future research directions.
This PrimeView highlights the pathophysiology of Alkaptonuria, a rare inherited metabolic disease, and summarizes its epidemiology, diagnosis and management. It accompanies the Primer article on this topic by Bernardini et al.
Alkaptonuria is a rare metabolic disease that has multisystemic and debilitating effects. In this Primer, Bernardini et al. summarize current knowledge of epidemiology and mechanisms, and discuss diagnosis, management and quality of life of patients with this disorder. They also highlight outstanding research questions.
This Primer by Zerr et al. discusses the epidemiology, pathophysiology, diagnosis and potential future treatments for Creutzfeldt–Jakob disease and other human prion diseases.
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that typically starts in childhood. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of ADHD.
Rotator cuff tears occur due to trauma or, most commonly, due to degenerative changes to tendon structure. This Primer summarizes the epidemiology and pathophysiology of this condition, discusses its diagnosis and management, and highlights patients’ quality of life and future research questions.
Strongyloidiasis is a helminth infection that is most common in tropical and subtropical regions. In this Primer, Gordon et al. review the global disease burden and risk factors, summarize the pathophysiology, diagnosis and prevention of this parasite infection, and provide an overview of its treatment and areas for future work.