Browse Articles

This PrimeView highlights the pathophysiology of rotator cuff tears and accompanies the Primer article on this topic by Feeley and colleagues.

Rotator cuff tears occur due to trauma or, most commonly, due to degenerative changes to tendon structure. This Primer summarizes the epidemiology and pathophysiology of this condition, discusses its diagnosis and management, and highlights patients’ quality of life and future research questions.

This PrimeView highlights the epidemiology of strongyloidiasis, as well as discussing mechanisms, diagnosis, management and outlook.

Strongyloidiasis is a helminth infection that is most common in tropical and subtropical regions. In this Primer, Gordon et al. review the global disease burden and risk factors, summarize the pathophysiology, diagnosis and prevention of this parasite infection, and provide an overview of its treatment and areas for future work.

This PrimeView highlights the mechanisms of perioperative stroke, and accompanies the Primer on this topic by Fanning et al.

Perioperative stroke — that is stroke occurring during or within 30 days of surgery — is associated with poor outcomes. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of perioperative stroke.

This PrimeView highlights the pathophysiology of pulmonary hypertension, as well as discussing epidemiology, diagnosis, management and quality of life.

Pulmonary hypertension describes a group of disorders characterized by elevated mean pulmonary artery pressure. This Primer reviews the epidemiology and pathophysiology of pulmonary hypertension, discusses diagnosis and management, and provides an overview of current open research questions.

This PrimeView highlights the epidemiology, pathophysiology, diagnosis and management of central neuropathic pain, a chronic pain condition caused by lesion of damage to the central somatosensory nervous system.

Central neuropathic pain (CNP), that is, pain caused by a lesion of disease of the central somatosensory nervous system, severely impacts quality of life. In this Primer, Finnerup and colleagues review the epidemiology, pathophysiology, clinical presentation and diagnosis of CNP as well as discuss common therapeutic strategies and unmet clinical needs in this field.

This PrimeView highlights the epidemiology, pathophysiology, diagnosis and management of typhoid fever as well as discuss prevention strategies and future research directions.

Typhoid fever is an invasive bacterial disease associated with bloodstream infection. This Primer summarizes the epidemiology, pathophysiology, diagnosis, prevention and management of typhoid fever. This Primer also discusses how this disease affects patients’ quality of life and suggests future research directions.

This PrimeView summarizes the pathophysiology of degenerative mitral regurgitation, a form of valvular heart disease.

This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of degenerative mitral regurgitation. This disorder is a type of valvular heart disease and occurs when there is direct damage to the mitral valve apparatus causing mitral leaflet coaptation failure.

This PrimeView highlights mechanisms underlying IgA nephropathy and accompanies the Primer article on this topic by Stamellou et al.

IgA nephropathy (IgAN) is an inflammatory disease of the glomerulus that can lead to kidney failure. In this Primer, Stamellou et al. discuss the prevalence and pathophysiological mechanisms of IgAN, summarize diagnosis and management of the disease, and provide an outlook on required future research.

Conversational agents (CAs) are computer programs designed to engage in human-like conversations with users. They are increasingly used in digital health applications, for example medical history taking. CAs have potential to facilitate health-care processes when designed carefully, considering quality aspects and are integrated into health-care processes.

This PrimeView highlights the management of scars and accompanies the Primer article on this topic by Jeschke et al.

Every injury of the skin undergoes a process known as wound healing. When wound healing is disrupted, excessive scars, such as hypertrophic scars and keloid lesions, can develop. This Primer summarizes the epidemiology, mechanisms, diagnosis and treatment of scars, as well as discussing how scars can affect an individual’s quality of life.