Unexplored opportunities in the druggable human genome

December 2016

Much of biomedical research and the development of therapeutics is focused on a small fraction of the human genome, ignoring many disease-relevant proteins and the associated scientific and commercial opportunities. The National Institutes of Health (NIH) Illuminating the Druggable Genome programme aims to catalyse research around understudied targets. As part of this effort, this poster presents a categorization of proteins in the human genome based on available data, information and knowledge from various sources. It also illustrates the commercial focus on therapeutic targets and associated disease areas, based on global drug sales data for a 5-year period. This analysis highlights a knowledge deficit, and points towards novel research and commercial opportunities for drug discovery and development.

The production and distribution of this poster was funded by the Illuminating the Druggable Genome Knowledge Management Center (IDG KMC), NIH grant U54CA189205. The poster content is peer reviewed and the responsibility of Macmillan Publishers Limited.