Advance online publication
The latest articles are published online ahead of print (AOP) on a weekly basis. These online versions are definitive and may be cited using the digital object identifier (DOI).
Article Types
Review
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
Liqing Wang, Edwin F. de Zoeten, Mark I. Greene & Wayne W. Hancock
Published online: 26 October 2009 | doi:10.1038/nrd3031
Many inhibitors of histone deacetylases (HDACs) are in trials in patients with cancer, but a subset of HDAC inhibitors also have anti-inflammatory or immunosuppressive effects that may be of therapeutic benefit in autoimmune diseases or post-transplantation. Hancock and colleagues describe these effects, highlighting the importance of the ability of some HDAC inhibitors to enhance the production and suppressive functions of FOXP3+ regulatory T cells, and discuss the potential to develop class- or subclass-specific HDAC inhibitors as novel immunotherapies.
Perspectives
Article series: A guide to drug discovery
Opinion
The future of drug development: advancing clinical trial design
John Orloff, Frank Douglas, Jose Pinheiro, Susan Levinson, Michael Branson, Pravin Chaturvedi, Ene Ette, Paul Gallo, Gigi Hirsch, Cyrus Mehta, Nitin Patel, Sameer Sabir, Stacy Springs, Donald Stanski, Matthias R. Evers, Edd Fleming, Navjot Singh, Tony Tramontin & Howard Golub
Published online: 09 October 2009 | doi:10.1038/nrd3025
Orloff and colleagues describe how moving from the traditional approach to clinical trials based on sequential, distinct phases towards a more integrated strategy that increases flexibility and maximizes the use of accumulated knowledge could have a key role in improving the efficiency and cost-effectiveness of drug development. Using examples in which novel trial designs have been successfully applied, they also illustrate the use of the tools involved, such as Bayesian methodologies, and discuss the advantages and challenges for their more widespread implementation.
About AOP
Until print versions of AOP papers are published, they should be cited in the style "Nature Reviews Drug Discovery AOP, published online day month year; doi:10.1038/nrdXXX". Once the print version (identical to the AOP) is published, it should be cited as follows: "Nature Reviews Drug Discovery volume number, page range (year); doi:10.1038/nrdXXX".
