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Denosumab

Nature Reviews Drug Discovery volume 9, pages 591–592 (2010)Cite this article

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Abstract

In May 2010, denosumab (Prolia; Amgen) was granted marketing authorization by the European Commission for the treatment of postmenopausal women with osteoporosis who are at increased risk of fracture, and for the treatment of bone loss associated with hormone ablation therapy in men with prostate cancer at increased risk of fracture. Shortly after, in June 2010, denosumab was approved by the US FDA for the treatment of postmenopausal women with osteoporosis at high risk of fracture.

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Acknowledgements

U.Y. would like to thank D. Hanicq for assistance in data collection.

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Authors and Affiliations

  1. René Rizzoli is at the Division of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospitals and Faculty of Medicine, 24, rue Micheli-du-crest, 1211, Geneva 14, Switzerland. Rene.Rizzoli@unige.ch,

    René Rizzoli

  2. Uma Yasothan is at IMS Health, 7 Harewood Avenue, London NW1 6JB, UK. uyasothan@de.imshealth.com,

    Uma Yasothan

  3. Peter Kirkpatrick is at Nature Reviews Drug Discovery. p.kirkpatrick@nature.com,

    Peter Kirkpatrick

Authors
  1. René Rizzoli
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  2. Uma Yasothan
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  3. Peter Kirkpatrick
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Competing interests

R.R. is an advisory board member for Amgen, Novartis, Roche, Servier, Nycomed, Danone and Merck.

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Rizzoli, R., Yasothan, U. & Kirkpatrick, P. Denosumab. Nat Rev Drug Discov 9, 591–592 (2010). https://doi.org/10.1038/nrd3244

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