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Nature Reviews Drug Discovery 8, 540 (1 July 2009) | doi:10.1038/nrd2931

Mood disorders: Channel inhibitor shows antidepressant potential

Monica Hoyos Flight

The molecular mechanisms underlying human depression are still poorly understood. At present, most drug therapies for this disorder exert their effects by enhancing monamine neurotransmission, but the onset of symptom relief is slow, and many patients fail to achieve full remission.