Abstract

In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

Author affiliations

1. Maurizio Pellecchia is at the Burnham Institute for Medical Research, La Jolla, 92037 California, USA.
2. Ivano Bertini and Claudio Luchinat are at the Magnetic Resonance Center, The University of Florence, 50019 Sesto Fiorentino, Italy.
3. David Cowburn is at the New York Structural Biology Center, New York, 10027 New York, USA.
4. Claudio Dalvit is at the Experimental Therapeutics Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), 28029 Madrid, Spain.
5. Ernest Giralt is at the Institute for Research in Biomedicine, Barcelona and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain.
6. Wolfgang Jahnke is at the Novartis Institute for BioMedical Research, 4002 Basel, Switzerland.
7. Thomas L. James is at the School of Pharmacy, University of California at San Francisco, 94158 California, USA.
8. Steve W. Homans is at the Institute of Molecular and Cellular Biology, University of Leeds, LS2 9JT UK.
9. Horst Kessler is at the Center of Integrated Protein Science at the Technische Universität München, Department Chemie, 85747 Munich, Germany.
10. Bernd Meyer is at the Institute for Organic Chemistry University of Hamburg, 20146 Hamburg, Germany.
11. Hartmut Oschkinat is at the Forschungsinstitut für Molekulare Pharmakologie, Berlin 13125, Germany.
12. Jeff Peng is at the University of Notre Dame, 46556 Indiana, USA.
13. Harald Schwalbe is at the Center for Biomolecular Magnetic Resonance, 60438 Frankfurt, Germany.
14. Gregg Siegal is at the Institute of Chemistry, Leiden University, 2300RA Leiden, The Netherlands.

Correspondence to: Maurizio Pellecchia¹ Email: mpellecchia@burnham.org

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