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Research Highlights
Nature Reviews Drug Discovery 7, 645 (1 August 2008) | doi:10.1038/nrd2645
Stem cells: Overcoming barriers to iPS cells
Abstract
The potential to reprogramme somatic cells into a pluripotent state to create patient-specific cells for regenerative medicine applications has attracted considerable interest in recent months. However, several important limitations — such as the tumorigenic potential of the transcription factor Myc and the use of retroviral infection — must be overcome before this technique can be broadly applied therapeutically.
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