FIGURE 5 | Hypothesis: TWEAK expression levels may dictate the predominant signalling mechanism in injured tissues and solid tumours.

From the following article:

The TWEAK–Fn14 cytokine–receptor axis: discovery, biology and therapeutic targeting

Jeffrey A. Winkles

Nature Reviews Drug Discovery 7, 411-425 (May 2008)

doi:10.1038/nrd2488

The TWEAK|[ndash]|Fn14 cytokine|[ndash]|receptor axis: discovery, biology and therapeutic targeting

a | Tissues in which basal TWEAK expression levels are high and basal Fn14 expression levels are low, minimal Fn14 receptor activation is expected. However, an increase in Fn14 expression; for example, following tissue injury, would trigger TWEAK-dependent Fn14 signalling. b | Tissues in which both basal TWEAK and Fn14 expression levels are low, minimal Fn14 receptor activation is expected. In this situation, an increase in Fn14 expression; for example, in response to tumour cell derived-growth factors, would trigger TWEAK-independent Fn14 signalling.

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