Review

Nature Reviews Drug Discovery 7, 438-455 (May 2008) | doi:10.1038/nrd2553

Targeting the endocannabinoid system: to enhance or reduce?

Vincenzo Di Marzo1  About the author

Top

As our understanding of the endocannabinoids improves, so does the awareness of their complexity. During pathological states, the levels of these mediators in tissues change, and their effects vary from those of protective endogenous compounds to those of dysregulated signals. These observations led to the discovery of compounds that either prolong the lifespan of endocannabinoids or tone down their action for the potential future treatment of pain, affective and neurodegenerative disorders, gastrointestinal inflammation, obesity and metabolic dysfunctions, cardiovascular conditions and liver diseases. When moving to the clinic, however, the pleiotropic nature of endocannabinoid functions will require careful judgement in the choice of patients and stage of the disorder for treatment.

Author affiliations

  1. Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council (CNR), Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy.

Correspondence to: Email: vdimarzo@icmib.na.cnr.it

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

NEWS AND VIEWS

Why endocannabinoids are not all alike

Nature Neuroscience News and Views (01 Feb 2008)

Decoding endocannabinoid signaling

Nature Chemical Biology News and Views (01 Jan 2009)

See all 5 matches for News And Views