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Research Highlights
Nature Reviews Drug Discovery 7, 203 (1 March 2008) | doi:10.1038/nrd2537
Cardiovascular disease: Hormone mimic reduces cholesterol
Abstract
Lowering levels of 'bad' cholesterol is a well-established approach to reduce the risk of cardiovascular disease (CVD), but a significant need remains for drugs that could help achieve this goal. Writing in PNAS, Baxter and colleagues present the first clinical data for a novel mimetic of thyroid hormone (TH) — KB2115 (eprotirome) — demonstrating its ability to lower cholesterol levels while lacking the adverse effects of TH itself.
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