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Editorial

Nature Reviews Drug Discovery 7, 959 (1 December 2008) | doi:10.1038/nrd2756

Apoptosis: a clinical perspective

Ernest C. Borden , Harriet Kluger & John Crowley

More than 140,000 articles have been published on molecules that mediate the intrinsic and extrinsic apoptotic cascades, such as BCL-2, TNF, NF-κB and p53. This interest in part stems from the substantial potential to therapeutically intervene in these pathways, as highlighted in this issue.