Figures and Tables

From the following article:

Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Avi Ashkenazi

Nature Reviews Drug Discovery 7, 1001-1012 (December 2008)

doi:10.1038/nrd2637

Figure 1 - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Figure 1

Key steps in apoptotic signalling pathways.

Figure 2 - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Figure 2

Pro-apoptotic receptor agonists.

Figure 3 - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Figure 3

Crystal structures of pro-apoptotic receptor agonists and DR5.

Figure 4 - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Figure 4

Potential modes of pro-apoptotic receptor activation by agonistic antibodies.

Figure 5 - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Figure 5

Identification of biomarkers that might predict tumour sensitivity to rhApo2L/TRAIL.

Table 1 - Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

Table 1

Clinical studies with pro-apoptotic receptor agonists