Review
Nature Reviews Drug Discovery 7, 841-853 (October 2008) | doi:10.1038/nrd2665
There is a Corrigendum (1 June 2009) associated with this article.
Sirtuins — novel therapeutic targets to treat age-associated diseases
Siva Lavu1, Olivier Boss1, Peter J. Elliott1 & Philip D. Lambert1 About the authors
Abstract
Sirtuins post-translationally modulate the function of many cellular proteins that undergo reversible acetylation–deacetylation cycles, affecting physiological responses that have implications for treating diseases of ageing. Potent small-molecule modulators of sirtuins have shown efficacy in preclinical models of metabolic, neurodegenerative and inflammatory diseases, and so hold promise for drug discovery efforts in multiple therapeutic areas. Here, we discuss current knowledge and data that strengthens sirtuins as a druggable set of enzymes for the treatment of age-associated diseases, including activation of SIRT1 in type 2 diabetes.
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Author affiliations
- Sirtris Pharmaceuticals, a GSK Company, 200 Technology Square, Cambridge, Massachusetts, 02139, USA.
Correspondence to: Philip D. Lambert1 Email: plambert@sirtrispharma.com
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