Review
Nature Reviews Drug Discovery 6, 556-568 (July 2007) | doi:10.1038/nrd2355
Utilizing RNA interference to enhance cancer drug discovery
Elizabeth Iorns1, Christopher J. Lord1, Nicholas Turner1 & Alan Ashworth1 About the authors
Abstract
With the development of RNA interference (RNAi) libraries, systematic and cost-effective genome-wide loss-of-function screens can now be carried out with the aim of assessing the role of specific genes in neoplastic phenotypes, and the rapid identification of novel drug targets. Here, we discuss the existing applications of RNAi in cancer drug discovery and highlight areas in this process that may benefit from this technology in the future.
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Author affiliations
- The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK.
Correspondence to: Alan Ashworth1 Email: Alan.Ashworth@icr.ac.uk
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