FIGURE 4 | NS5B RNA replicase inhibitors: part 1.
From the following article:
The design of drugs for HIV and HCV
Erik De Clercq
Nature Reviews Drug Discovery 6, 1001-1018 (December 2007)
doi:10.1038/nrd2424
a | Mechanism of action of nucleoside RNA replicase inhibitors (NRRIs) as exemplified for valopicitabine (2'-C-methylcytidine) and 4'-azidocytidine. Three phosphorylation steps convert the nucleoside analogues (that is, 2'-C-methylcytidine or 4'-azidocytidine) to their 5'-triphosphates, which then act as non-obligate chain terminators (in competition with the natural substrate CTP) of the HCV NS5B RNA-dependent RNA polymerase (RdRp) as they interfere with further elongation through steric hindrance. b | Structures of NRRIs.
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