FIGURE 2 | Human immunodeficiency virus (HIV) reverse transcriptase.
From the following article:
The design of drugs for HIV and HCV
Erik De Clercq
Nature Reviews Drug Discovery 6, 1001-1018 (December 2007)
doi:10.1038/nrd2424
a | Three-dimensional structure of HIV-1 reverse transcriptase, with the fingers, palm, thumb, connection and RNase H domains, belonging to the p66 subunit, and the p51 subunit, based on Ref. 9. b | HIV-1 reverse transcriptase complexed with the DNA template primer. The reverse transcriptase heterodimer consists of the p66 subunit (dark blue) and the p51 subunit (light blue). The two magnesium ions in the active site are shown as purple balls. The side-chains of active-site amino acids Y183, M184, D185, D186 and D10 are represented as green-coloured van der Waals spheres. Residues of the non-nucleoside reverse transcriptase inhibitor binding site (L100, K101, K103, V106, V108, V179, Y181, Y188, P225, F227, W229, L234, P236 and Y318) are represented as yellow-coloured van der Waals spheres10. Figure reproduced with permission from Ref. 10 © (2004) Elsevier Science Ltd.
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