Declaration of competing financial interests

Declaration: The authors declare that they have no competing interests that constitute a conflict of interest for content and interpretations contained herein with the following exceptions: E.C.B. is a member of the Scientific Advisory Boards of Cleveland BioLabs and Alios BioPharma and in the past 3 years that of Coley Pharma together with honoaria for scientfic or educational presentations underwritten by Schering Plough, Maxygen, and Novartis; R.H.S. is a member of the Scientific Advisory Board of Alios BioPharma, Inc.; G.R.F. has lectured and consulted for Roche, Maxygen, Novartis, and Human Genome Sciences. Within the past 5 years, R.M.R. has received occasional honouraria for scientific presentations from (in alphabetical order) Berlex, Biogen and Serono. These presentations did not serve marketing interests.