Declaration of competing financial interests

Declaration: During the preparation of this manuscript and for 12 months prior, the author received research grant support from Boehringer–Ingelheim Inc., Bristol–Myers Squibb and GlaxoSmithKline; served on scientific advisory boards for Boehringer–Ingelheim Inc., Bristol–Myers Squibb, Inhibitex Inc., Merck Pharmaceuticals, Tibotec Pharmaceuticals and Vertex Pharmaceuticals; and received lecture honoraria from Abbott Laboratories, Gilead Pharmaceuticals and GlaxoSmithKline.