Figures and Tables

From the following article:

Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Robyn P. Araujo, Lance A. Liotta & Emanuel F. Petricoin

Nature Reviews Drug Discovery 6, 871-880 (November 2007)

doi:10.1038/nrd2381

Figure 1 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 1

An example of a composite feedback control module.

Figure 2 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 2

A minimal network representation for the dual regulation of IRS1 activity by AKT.

Figure 3 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 3

A schematic depicting the four classes of targeted therapy for the composite network motif regulating insulin receptor substrate 1 (IRS1) activity.

Figure 4 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 4

A comparison of four molecularly targeted therapies for the composite insulin receptor substrate 1 (IRS1) regulatory motif as illustrated in figure 3.

Figure 5 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 5

A simple network schematic for a kinase cascade regulated by an oncoprotein on which cell viability is strictly dependent.

Figure 6 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 6

Network output corresponding to the reaction scheme and mathematical model outlined in figure 5.

Figure 7 - Proteins, drug targets and the mechanisms they control: the simple truth about complex networks

Figure 7

Combination therapies and their potential to combat the problem of tumour recurrence following a successful therapy.