Figures and Tables

From the following article:

Flying under the radar: the new wave of BCR–ABL inhibitors

Alfonso Quintás-Cardama, Hagop Kantarjian & Jorge Cortes

Nature Reviews Drug Discovery 6, 834-848 (October 2007)

doi:10.1038/nrd2324

Figure 1 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Figure 1

Oncogenic signalling of BCR–ABL kinase.

Figure 2 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Figure 2

Structural organization of BCR–ABL and SFKs.

Figure 3 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Figure 3

Different modes of BCR–ABL binding.

Table 1 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Table 1

Haematological and cytogenetic responses to nilotinib and dasatinib*

Table 2 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Table 2

Imatinib compared with a selection of promising dual ABL/SFK inhibitors in clinical and preclinical development*

Table 3 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Table 3

Imatinib compared with a selection of promising dual ABL/SFK inhibitors in clinical and preclinical development*

Table 4 - Flying under the radar: the new wave of BCR|[ndash]|ABL inhibitors

Table 4

Selected compounds with activity against BCR–ABL T315I kinase