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The digital information revolution has led to the rapid development of many countries, causing the pharmaceutical industry to face a new array of Asia-specific challenges. Epstein discusses how understanding Asia's diverse cultures, talents and markets will bring about success for the industry.
Retinoic acid receptors (RARs) are ligand-controlled transcription factors that function as heterodimers with retinoid X receptors (RXRs) to regulate cell growth and survival. This article discusses recent advances in the understanding of the biological role of RARs and RXRs and their implications for the design of selective receptor modulators for cancer and metabolic diseases.
Retinoic acid receptors (RARs) are important drug targets for cancer therapy and prevention, and the potential of rexinoids for the treatment of metabolic diseases is increasingly being recognized. This article reviews recent structural data for RARs and retinoid X receptors (RXRs), discusses strategies in the design of selective RXR and RAR modulators, and consider lessons that can be learned for the design of selective nuclear-receptor modulators in general.
In this Review, Clemmons discusses how strategies to utilize IGF1's growth stimulating and anabolic properties are being pursued to treat short stature, catabolism and diabetes, and highlights the potential benefit of IGF1 antagonism in cancer therapy.
Chronic myeloid leukaemia caused by the mutant BCR–ABL kinase has been successfully treated with inhibitors of this kinase, such as imatinib, but mutations within the kinase can result in resistance to these drugs. Quintás-Cardama and colleagues discuss novel BCR–ABL inhibitors that have the potential to overcome such resistance.
