FIGURE 1 | Cartoon of a normal joint and rheumatoid arthritis joint.

From the following article:

Biologic therapies in rheumatology: lessons learned, future directions

Vibeke Strand, Robert Kimberly & John D. Isaacs

Nature Reviews Drug Discovery 6, 75-92 (January 2007)

doi:10.1038/nrd2196

Biologic therapies in rheumatology: lessons learned, future directions

In the healthy joint (a) the thin synovial membrane lines the non-weight-bearing aspects of the joint. In rheumatoid arthritis (b) the synovial membrane becomes hyperplastic and infiltrated by chronic inflammatory cells. Ultimately it develops into 'pannus', which migrates onto and into the articular cartilage and underlying bone.

Download file

If the slide opens in your browser, select "File > Save As" to save it.