TABLE 3 | Selected compounds affecting T-cell-activation pathways

From the following article:

Targeting signal transduction as a strategy to treat inflammatory diseases

Luke A. J. O'Neill

Nature Reviews Drug Discovery 5, 549-563 (July 2006)

doi:10.1038/nrd2070

CompoundStructureTargetCommentsRefs
ISA247Targeting signal transduction as a strategy to treat inflammatory diseasesCalcineurinPhase III clinical trials for psoriasis50
FTY720Targeting signal transduction as a strategy to treat inflammatory diseasesSphingosine-1-phosphate receptorPhase III clinical trials for multiple sclerosis53
RapamycinTargeting signal transduction as a strategy to treat inflammatory diseasesmTORApproved for transplantation54
EverolimusTargeting signal transduction as a strategy to treat inflammatory diseasesmTORPhase II clinical trials for rheumatoid arthritis57
TemsirolimusTargeting signal transduction as a strategy to treat inflammatory diseasesmTORPhase II clinical trials for multiple sclerosis58

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