Perspectives
Nature Reviews Drug Discovery 5, 377-380 (May 2006) | doi:10.1038/nrd2036
Essay: Integrative pharmacology and drug discovery — is the tide finally turning?
Michael G. Collis1 About the author
Abstract
In vivo animal experiments are essential (and a regulatory requirement) to demonstrate the potential efficacy, safety and pharmacodynamic/pharmaco-kinetic profile of candidate drugs. However, the number of pharmacologists (and other bioscientists) with integrative (in vivo) pharmacology skills has been in decline for a number of years, as have the opportunities for students to learn such skills. This article reviews some recent initiatives that are underway to rebuild this essential skills base in the United Kingdom and the United States. Partnerships between industry and national funders of research and education have proved to be a particularly effective approach to support this strategically important area of biological science.
Author affiliations
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Michael G. Collis is at the British Pharmacological Society, 16 Angel Gate, City Road, London, EC1V 2SG, UK
Email: mc@bps.ac.uk
Published online 21 April 2006
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