Review
Nature Reviews Drug Discovery 5, 310-321 (April 2006) | doi:10.1038/nrd2006
Multiplexed protein measurement: technologies and applications of protein and antibody arrays
Stephen F. Kingsmore1 About the author
Abstract
The ability to measure the abundance of many proteins precisely and simultaneously in experimental samples is an important, recent advance for static and dynamic, as well as descriptive and predictive, biological research. The value of multiplexed protein measurement is being established in applications such as comprehensive proteomic surveys, studies of protein networks and pathways, validation of genomic discoveries and clinical biomarker development. As standards do not yet exist that bridge all of these applications, the current recommended best practice for validation of results is to approach study design in an iterative process and to integrate data from several measurement technologies. This review describes current and emerging multiplexed protein measurement technologies and their applications, and discusses the remaining challenges in this field.
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Author affiliations
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National Center for Genome Resources, 2935 Rodeo Park Drive East, Santa Fe, New Mexico 87505, USA.
Email: sfk@ncgr.org
Published online 17 March 2006
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